' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.3
USERS' SCORE
Very Good
Based on 5 Reviews
7.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Highly relevant to heart health
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
VD3 improves heart attack outcomes
Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway.
High relevance to heart health
We explored the impact of 1,25-dihydroxyvitamin D3 (VD3) on heart health, particularly after an acute myocardial infarction (AMI). To investigate this, we used male C57/BL6J mice and conducted a series of experiments, comparing those treated with VD3 to control groups.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Read More
8
Vitamin D impacts heart attack severity
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Direct link to vitamin D and heart health.
We explored the impact of vitamin D levels on heart attack severity by examining 77 patients who experienced ST-elevation myocardial infarction (STEMI). A key focus was to understand how vitamin D deficiency might relate to the amount of thrombus, or blood clots, present in coronary arteries.
The findings revealed that a striking 79.22% of patients had vitamin D levels below what is considered adequate (less than 20 ng/mL). Notably, those with mild thrombus loads had higher vitamin D levels compared to those classified with severe thrombus loads, indicating a clear connection.
Furthermore, we discovered a negative correlation between vitamin D levels and the severity of thrombus. The lower the vitamin D levels, the higher the thrombus burden and the post-procedural TIMI frame count—essentially metrics that show how blood flows in the heart after treatment. This highlights that maintaining adequate vitamin D might be crucial for individuals at risk of severe heart complications.
The findings revealed that a striking 79.22% of patients had vitamin D levels below what is considered adequate (less than 20 ng/mL). Notably, those with mild thrombus loads had higher vitamin D levels compared to those classified with severe thrombus loads, indicating a clear connection.
Furthermore, we discovered a negative correlation between vitamin D levels and the severity of thrombus. The lower the vitamin D levels, the higher the thrombus burden and the post-procedural TIMI frame count—essentially metrics that show how blood flows in the heart after treatment. This highlights that maintaining adequate vitamin D might be crucial for individuals at risk of severe heart complications.
Read More
Most Useful Reviews
6.8
Improved mental clarity
While I didn’t feel less tired, my stamina improved. After a good night’s sleep, I wake up alert. This supplement hasn't dramatically changed my life, but I haven’t suffered from headaches or high blood pressure for three months. Panic attacks and anxiety have also diminished.
Read More
8.8
No symptoms reported
Easy to take. If it is 5000 IU, an overdose could cause hypercalcemia, leading to calcium deposits in blood vessels, kidneys, and lungs, resulting in renal dysfunction, anorexia, and vomiting. Thankfully, I have experienced none of these symptoms and my heart feels somewhat improved.
Read More
4.5
Addressing vitamin D3 deficiency
I took this brand for nearly two years and later discovered a significant vitamin D3 deficiency. I now use a liquid form for better absorption. Vitamin D is vital for health, but both deficiency and excess can be harmful. It plays a crucial role in reducing the risk of various conditions, including heart attack.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.3
9.5
Vitamin D3 enhances heart recovery
Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats.
Moderate relevance for heart recovery
We conducted a detailed study to uncover how vitamin D3, combined with exercise, affects recovery from heart attacks. Our research involved fifty-six male rats, some of which experienced a simulated heart attack, while others served as a control group.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
Read More
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Highly relevant to heart health
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
Vitamin D3 protects heart function
Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy.
Relevant study on vitamin D3
We explored the effects of vitamin D3 on heart injury caused by ischemia/reperfusion (I/R), a common scenario during heart attacks. Using a laboratory model that mimicked this condition, we discovered that I/R treatment significantly harmed heart cells, leading to cell death and increased oxidative stress.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
Read More
9
VD3 improves heart attack outcomes
Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway.
High relevance to heart health
We explored the impact of 1,25-dihydroxyvitamin D3 (VD3) on heart health, particularly after an acute myocardial infarction (AMI). To investigate this, we used male C57/BL6J mice and conducted a series of experiments, comparing those treated with VD3 to control groups.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Read More
8
Effects of n-3 on heart attacks
Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes.
Low relevance to vitamin D3
We examined the effects of marine n-3 fatty acids, alongside vitamin D3, on cardiovascular disease events, particularly heart attacks. In the VITAL trial, which involved nearly 26,000 healthy older adults, participants were given either a supplement of n-3 fatty acids or a placebo to see if it would lower the risk of significant heart events.
The findings indicated a modest, though not significant, benefit of n-3 fatty acid supplementation regarding heart attacks. Specifically, the study revealed that while there was a reduction in non-fatal heart attacks, there was no clear impact on stroke outcomes. Interestingly, those with lower fish consumption at the start showed a stronger benefit from the n-3 fatty acids compared to their counterparts who consumed more fish.
However, it's important to note that the evaluation did not find any substantial isolated effect of vitamin D3 on heart attacks. Overall, our study suggests that while n-3 fatty acids might have some positive effects, particularly in certain groups, the same cannot be confidently stated for vitamin D3 alone in preventing heart attacks.
The findings indicated a modest, though not significant, benefit of n-3 fatty acid supplementation regarding heart attacks. Specifically, the study revealed that while there was a reduction in non-fatal heart attacks, there was no clear impact on stroke outcomes. Interestingly, those with lower fish consumption at the start showed a stronger benefit from the n-3 fatty acids compared to their counterparts who consumed more fish.
However, it's important to note that the evaluation did not find any substantial isolated effect of vitamin D3 on heart attacks. Overall, our study suggests that while n-3 fatty acids might have some positive effects, particularly in certain groups, the same cannot be confidently stated for vitamin D3 alone in preventing heart attacks.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 5 Reviews
7.4
8.8
No symptoms reported
Easy to take. If it is 5000 IU, an overdose could cause hypercalcemia, leading to calcium deposits in blood vessels, kidneys, and lungs, resulting in renal dysfunction, anorexia, and vomiting. Thankfully, I have experienced none of these symptoms and my heart feels somewhat improved.
8.8
Better heart health
The value of vitamin D for my body is significant. It maintains bone health and reduces the chances of heart attack and stroke. I’ve been taking this supplement daily for about two years, and I've noticed I feel more cheerful with fewer headaches. The small capsules are convenient to swallow.
Read More
8.8
Healthy immune system
Vitamin D3 is critical for a healthy immune system, and those supplementing experience fewer viral symptoms and a reduced risk of autoimmune diseases. My mother, who is 83, and I both take 70,000 IU weekly. We recovered well from Covid, thanks to this supplement.
6.8
Improved mental clarity
While I didn’t feel less tired, my stamina improved. After a good night’s sleep, I wake up alert. This supplement hasn't dramatically changed my life, but I haven’t suffered from headaches or high blood pressure for three months. Panic attacks and anxiety have also diminished.
Read More
4.5
Addressing vitamin D3 deficiency
I took this brand for nearly two years and later discovered a significant vitamin D3 deficiency. I now use a liquid form for better absorption. Vitamin D is vital for health, but both deficiency and excess can be harmful. It plays a crucial role in reducing the risk of various conditions, including heart attack.
Read More
